OSAS diagnosis must be very accurate. Diseases of the upper respiratory tract which contribute to sleep respiratory disorders are very widespread. The constantly evolving methods of minimally invasive surgery help in restoring the airway patency and are based on the latest generation radio frequencies-RF (Quantum Molecular Resonance), and balloon catheters both dilative (Thinvasive DRB System) and with kinetic oscillation stimulation (KOS Ozilia) spare healthy tissues. A very innovative drug delivery system called Molecular Vaporizer-MV (Nutrintech Med Italia, Rome, Italy) which allows to obtain dry steam has been developed and used by our research team to administrate respiratory drugs also in OSAS to restore the proper respiratory airflow.